TTF-1 and Napsin A double stain

TTF-1 [SPT24] Staining Specificity in Lung Adenocarcinoma vs. Lung Squamous Cell Carcinoma is Markedly Improved with Titer Optimization and Cut-Off Values

Materials and Methods Formalin-fixed paraffin-embedded lung SqCC (n=137) and LADC (n=60) tissue microarrays were acquired. DSG3/p40 + Napsin A double stain cocktail (Biocare Medical, Concord, CA), TTF-1 [SPT24] and TTF-1 [8G7G3/1] antibody titers were optimized for IHC. SPT24 was optimally titered at 1:1200. The double stain antibody cocktail was detected by using a polymer double stain detecti...

Non-small Cell Lung Carcinomas Lacking Morphologic Differentiation on Biopsy Specimens: Utility of an Immunohistochemical Panel Containing TTF-1, Napsin

Clinical significance of TTF‐1 protein expression and TTF‐1 gene amplification in lung adenocarcinoma

The majority of lung adenocarcinomas express the lineage-specific thyroid transcription factor-1 (TTF-1). We recently reported that in a subset of lung adenocarcinomas the TTF-1 gene is amplified. Although the prognostic significance of TTF-1 expression has been previously investigated, the significance of TTF-1 amplification has not been established. We studied 89 consecutive patients with lun...

2 Ttf Tcnq Ttf Tcnq Ttf Tcnq Ttf Tcnq

Laura Cano-Cortés, Andreas Dolfen, Jaime Merino, Jörg Behler, Bernard Delley, Karsten Reuter, and Erik Koch ∗ Departamento de Física Teórica de la Materia Condensada, Universidad Autónoma de Madrid, 28049 Madrid, Spain Institut für Festkörperforschung, Forschungzentrum Jülich, 52425 Jülich, Germany Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, 14195 Berlin, Germany Paul-Sche...

Immunoexpression of napsin a in renal neoplasms

BACKGROUND Immunohistochemistry (IHC) for napsin A has been widely used to support a diagnosis of lung adenocarcinoma with high sensitivity. In this study, we evaluated immunoreactivity for napsin A in a broad spectrum of renal neoplasms by using tissue microarrays (TMA). METHODS Duplicate TMA of 159 surgically excised renal neoplasms of various types were constructed. IHC for napsin A was pe...